SATB2 (ингл. SATB homeobox 2) — кешенең 2-нче хромосомасы аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.

2019-02-06

At an H‐score cutoff of ≥150, SATB2 was 69% sensitive/90% specific for Merkel cell carcinoma. SATB2 is a novel, sensitive marker for colorectal carcinoma. We hypothesized that SATB2 IHC can reliably identify primary and metastatic signet ring cell carcinomas of lower GI tract origin. SATB2 and CDX2 IHC was performed on 159 primary (n=93) and metastatic (n=66) signet ring cell carcinomas of GI tract origin and 13 metastatic breast carcinomas with signet ring cell features. 2019-01-01 Addie is one of less than 200 people in the world diagnosed with SATB2 syndrome.She was hesitant to sit on the couch for an interview, so I joined Addie on t SATB2 is a transcriptional regulator involved in osteoblastic and neuronal differentiation and is a sensitive and specific marker of colorectal epithelium. This study aimed to evaluate the expression of SATB2 in NNs from various primary sites and its utility as a marker in determining the site of origin of these neoplasms.

SATB2 is a novel, sensitive marker for colorectal carcinoma. We hypothesized that SATB2 IHC can reliably identify primary and metastatic signet ring cell carcinomas of lower GI tract origin. SATB2 and CDX2 IHC was performed on 159 primary (n=93) and metastatic (n=66) signet ring cell carcinomas of GI tract origin and 13 metastatic breast carcinomas with signet ring cell features. Expression of SATB2 (FLJ21474, KIAA1034) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ▽ Description. The SATB2 gene encodes a nuclear matrix DNA-binding protein that specifically binds to genomic nuclear matrix attachment regions and The promising findings of highly selective SATB2 expression in tumor cells from several retrospective cohorts of CRC and the combination of using IHC with 31 พ.ค.

SATB2 was expressed by 79% of Merkel cell carcinomas (median H‐score of 300), 33% of lung NECs (median H‐score of 23), and 60% of extrapulmonary visceral NECs (median H‐score of 110), with stronger expression in Merkel cell carcinoma (P < 0.001). At an H‐score cutoff of ≥150, SATB2 was 69% sensitive/90% specific for Merkel cell carcinoma.

Anti-SATB2 antibody produced in rabbit Antibody Enhanced Validation. Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered SATB2 : Identification of colorectal carcinoma and rectal neuroendocrine tumors. 25 Feb 2021 SATB2 is a biomarker for colorectal cancer, 85% of all CRC patients are positive for SATB2 and other cancer types rarely display SATB2 Detect Special AT-rich sequence-binding protein 2 using this rabbit polyclonal antibody, Anti-SATB2 Antibody validated for use in western blotting, IHC (Paraffin ) We need your help in understanding the impact of Ensembl in your research.

SATB2-associated syndrome (SAS) is a multisystem disorder characterized by significant neurodevelopmental compromise with limited or absent speech, behavioral issues, and craniofacial anomalies. The following clinical findings, based on published reports of 76 individuals with a …

Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Human. Cited in 30 publication(s). and SATB2 expression in periampullary adenocarcinoma has not yet been described. Methods: Immunohistochemical expression of SATB1 and SATB2 was analysed in tissue microarrays with primary tumours and a subset of paired lymph node metastases from 175 patients operated with pancreaticoduodenectomy for periampullary adenocarcinoma.

In a previous study, we identified Satb2 as a gene that is expressed predominantly in young UL neurons but not in SVZ progenitors (Britanova et al., 2005). SATB2 is a nuclear matrix attachment region-binding transcription factor with developmental role in craniofacial, neural, and osteoblastic differentiation. Several publications have documented SATB2 expression in the epithelium of the lower gastrointestinal tract (appendix, colon, and rectum). Aims: Special AT-rich sequence-binding protein 2 (SATB2) is a transcriptional regulator with critical roles in brain, craniofacial and skeletal development.
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Ovarian mucinous adenocarcinoma. All tissues were fixed in 10% neutral buffered formalin. Criteria for assessing a SATB2 staining as optimal included: 2012-02-21 Special AT-rich sequence-binding protein 2 (Satb2) is a protein binding to the matrix attachment regions of DNA and important for gene regulation. Patients with SATB2 mutation usually suffer moderate to severe mental retardation. However, the mechanisms for the defects of intellectual activities in patients with SATB2 mutation are largely unclear.

Colon neuroendocrine tumour, 7. Ovarian mucinous adenocarcinoma.
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SATB2 Awareness Day. August 22 marks an amazing opportunity for SATB2-associated syndrome (SAS), the SATB2 Gene Foundation and the SATB2 Gene Trust UK. Because this day is one where we can all come together to spread the word about SAS.

Southampton (UK): NIHR Journals Library; 2020 Jan. (Health Services and Delivery Research, No. 8.5.) SATB2 (SATB homeobox 2) is an AT rich DNA-binding protein. It is a homologue of SATB1 protein. This gene is localized to human chromosome 2q33.1, and is highly conserved across different species. Immunogen SATB homeobox 2 recombinant protein epitope signature tag (PrEST) Application Expression of SATB2 (FLJ21474, KIAA1034) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. Summary of SATB2 (FLJ21474, KIAA1034) expression in human tissue.